Hoyeraal Hreidarsson syndrome

30-month-old Girl Child Survives Hoyeraal Hreidarsson Syndrome

“Never lose hope, storms make people stronger and never last forever”- Roy T. Bennett. 

Meera’s (name changed) sufferings had no end. An 8-month premature girl born in Jan 2016, was admitted for 8 days in the hospital. She barely weighed 1.78 kgs. After six months, severe fever and rashes led to a 10 day-long hospitalization. Complete blood count (CBC) tests were performed to evaluate her health. In the CBC test, her platelets were exceedingly low.  Post Bone Marrow aspiration, Meera was diagnosed with Thrombocytopenia – abnormal low-levels of platelets. Eventually, the fever subsided and she was discharged. 

As Meera’s condition was not improving, parents consulted the family pediatrician and were suggested to transfer her to a corporate hospital in Hyderabad. Another CBC test was done. The platelet count was low – 50,000. They were advised to follow up once every month with CBC reports as no treatment was available. 

Meera’s condition was getting worse. She had a shocking weight loss after which the doctor recommended Bone Marrow Aspiration/ Biopsy for correct diagnosis. Diagnosed with Thrombocytopenia with Anemia, Meera’s parents were suggested to wait till her platelet dropped to 20,000.

In August 2017, Meera had a high fever and a severe case of Thrombocytopenia with Anemia. SDP platelets were transfused due to extremely low platelet count. Platelets/blood were transfused every month. It was a very hard time for the family. They could not watch their daughter’s suffering. Fortunately, Meera’s parents got in touch with AHIRAA donors on WhatsApp. A doctor at a corporate hospital referred Meera’s parents to Dr. S.K.Gupta for the possibility of a Bone Marrow Transplant

A doctor from the Genetic Department at a public hospital proposed a Genetic Test. The doctor advised them to go ahead with the Bone Marrow Transplant. The possibility of a BMT frightened Meera’s parents. With the risks involved and the finances, the chances of BMT looked bleak. Meera’s grandparents were afraid as no one gave a 100% guarantee of the procedure’s success. 

Meera’s parents contemplated and tried homeopathy medicine. 12 platelets transfusion and 8 blood transfusions were performed between Aug 2017-May 2018. During this period Meera had a high fever and caught infections.

The family finally consulted Dr. S.K.Gupta who explained the procedure and assured them that the BMT has a 70% success rate. 

The HLA match of the parents was negative. Both of them were half-matched. After the tests, the family was heartbroken. Dr. S.K.Gupta advised the HLA testing of Meera’s 16-month-old sister. The parents were panicking as they couldn’t process the thought of a 16-month-old baby donating stem cells. Dr.S.K.Gupta assured that the procedure will cause no harm to their younger daughter. The 16-month-old sister was a 100% HLA match. Meera’s family’s happiness knew no bounds. 

On 13 May 2018 Meera was admitted to the Hematology BMT Institute International located in Hyderabad. The parents were asked to arrange 5/5 donors for platelets and WBC. 

Chemotherapy began and lasted for a week. It was a difficult time for the family as both of their daughters were involved in the BMT. Stem Cells from Meera’s sister were collected and the procedure started. After 12-13 infusions, Meera showed positive signs. Unlike other transfusions that were performed in different hospitals; this time Meera showed no signs of fever or infections. No platelets or WBC were transfused during the 20-day hospitalization. Parents were delighted as they finally took a breath of relief.

According to Dr. S.K.Gupta, the initial 6 months- 1 year period is crucial after BMT. The patients might need re-admission. After 45 days of the procedure, Meera had a severe infection and her platelets dropped to 40K-50K. She recovered quickly. It’s been six months now and she has been doing great.

Meera was suffering from Hoyeraal Hreidarsson syndrome which was diagnosed by the team at Hematology BMT Institute International. 

What is Hoyeraal Hreidarsson Syndrome?

Hoyeraal Hreidarsson syndrome is a rare disease that is even more critical and complicated than cancer. It is an extremely rare multisystem X-linked recessive disorder.

Meera’s parents hold Dr. S.K.Gupta and the team at HBII in high regard. Parents were apprehensive about the cost of the BMT as they came across hospitals that charged an enormous amount. A government employee at a police department could only dream of saving his child with a BMT procedure. 

Dr. S.K.Gupta, the founder of Hematology BMT Institute International believes that every life is worth saving. Hematology BMT Institute International advocated no unnecessary admissions, medications, and blood transfusions. Promoting affordable healthcare and superior quality, Hematology BMT Institute International is making procedures like BMT more accessible to the needy.




A diagnosis of blood cancer can change lives; not only for the patients but also for their family and friends who love them. Let’s look at Bhavya’s (name changed) cancer treatment journey and experience with Dr. S.K. Gupta at Hematology BMT Institute International

Bhavya was 6 years old when she was diagnosed with blood cancer. It all started in mid-January 2019 when she started suffering from fever, cough, and cold. She also started losing weight drastically. Her family took her to a local hospital at Shadnagar but no difference was seen in her health. As time passed by, the fever started rising along with tremendous weight loss and mouth ulcers. The Government Hospital at Shadnagar conducted various tests and asked her family to take her to any good hospital. Later, Bhavya’s family took her to their native place located in Solapur, Maharashtra.

In March 2019, she was admitted to Markandeya Sahakari Rugnalaya under the observation of Dr. Shrishi Keyur. Treatments started and several tests were performed. The doctor after studying the results told Bhavya’s uncle that Bhavya is diagnosed with cancer. Her family tried consulting various other doctors but none of them matched their expectations. Finally, Bhavya’s uncle, Anand (name changed) insisted on consulting a Paediatric Hematologist, Dr. Dhinanth Mangeshkar in Pune.  The doctor informed the family that Bhavya is suffering from blood cancer and it has already spread across 95% of her body. The doctor insisted on starting the treatment immediately.

Amidst the dilemma, Bhavya’s family came to know about Dr. S.K. Gupta, senior consultant and founder at Hematology BMT Institute International, Hyderabad. Upon reaching the hospital, Prema, Dr. Gupta’s assistant, received them and took a brief medical history of Bhavya. Dr. Gupta guided Bhavya and her family through blood cancer and its treatments. Her family felt relaxed after receiving the doctor’s counseling. Bone marrow, Fisher mark, and other tests were done to understand what exactly is the case. Dr. Gupta then started Chemotherapy, which was a difficult phase for Bhavya and her family. Bhavya’s Chemotherapy lasted for 4 months. It was a difficult phase especially when the WBCs and platelet count were being closely monitored. During these times, the hospital management was so keen and supportive that it made it easier for the family to stay strong. Dr. Gupta spent time listening and answering the patient and her family member’s questions. He treated Bhavya as his child and played with her during his visits, which motivated her for a faster recovery. 

Bhavya’s mother said, “A heartfelt thanks to Dr. Gupta for my daughter’s second birth. Thanks to the management and staff for their all-time support. It was a great experience at Hematology and BMT Institute International.”

Dr. S.K. Gupta is a renowned hematologist in India with experience of over 15 years, practicing as a senior hematology consultant at Hematology BMT Institute International. He is an expert in treating blood, bone marrow, lymph nodes, and spleen disorders. Dr. S.K. Gupta strongly believes that the cornerstones of fruitful outcomes even in life-threatening hematological disorders are early diagnosis, proper guidance, and support. Adequate monitoring of the patient’s condition, improving the morale of both the patient and the family, are also crucial steps in reducing morbidity and mortality during treatment. 

At Hematology BMT Institute International, we have the best cancer doctors, who specialize in treating blood cancer with surgery, chemotherapy, bone marrow transplant, biological therapy, and hemato-oncology.


Book an appointment with Dr. S.K. Gupta, an experienced cancer specialist at Hematology BMT Institute International, one of the best cancer hospitals in India. Visit our website https://hematologybmt.com/ or call us at +91 7780297660. 


Multiple myeloma treatment in Hyderabad


Cancer begins when the cells start growing out of control. Cells can become cancerous in nearly every part of the body, and may spread to other areas. Let’s talk about Multiple myeloma, which is also known as Plasma cell cancer. The bone marrow finds normal plasma cells as an integral part of the immune system. The immune system consists of several types of cells, which work together to fight infections and other diseases. 

In the immune system, lymphocytes (lymph cells) are one of the major types of white blood cells, which include T cells and B cells. There are lymphocytes in many areas of the body, including lymph nodes, bone marrow, intestines, and bloodstream.

When blood cells respond to an infection, they ripen and mutate into plasma cells. Plasma cells then create antibodies that help the body kill germs.  Plasma cells are found in the bone marrow, the soft tissue inside the bones. Bone marrow is also the place of other blood cells, such as red blood cells, white blood cells, and platelets. 

In general, multiple myeloma is the condition when the plasma cells become cancerous and grow out of control. The plasma cells make an unusual protein (antibody) known by various names such as monoclonal immunoglobulin, monoclonal protein (M-protein), M-spike, or paraprotein. A person who has myeloma will find paraprotein often in the blood and urine. Tests of blood and urine are the means to diagnose and monitor myeloma. 

Multiple Myeloma does not constitute a lump or a tumor, however, most of the problems that it causes are due to a build-up of abnormal plasma cells in the bone marrow and body paraprotein. Myeloma affects those areas where your bone marrow is active. This includes your arms, legs, shoulders and spine, skull, pelvis, and rib cage. Myeloma affects several places in the body which is why it is referred to as multiple myeloma.

Blood and Myeloma

To understand why myeloma affects one’s body, it is important to know what and how blood cells are produced. Usually, when a body needs blood, the bone marrow makes blood cells in a controlled way. All the blood cells originate from the same cell type, called a stem cell. As they develop (mature), they transform into one of the three blood cell types: RBCs, WBCs, and Platelets.

Plasma cells develop from a type of white lymphocytes called B blood cells. Too many plasma cells are made in myeloma, and all are of the same kind. They clutch onto the bone marrow, which means there is insufficient space to make normal white cells, red cells, and platelets. The symptoms of multiple myeloma include bone problems, low blood counts, hypercalcemia, spinal cord compressions, nerve damage, hyperviscosity, kidney problems, and infections. 

To know more about the treatment of Multiple Myeloma and its symptoms, please consult Dr. S. K Gupta.
Dr. S. K Gupta is one of the best hemato-oncologists based in Hyderabad. He is an expert in treating disorders like blood, bone marrow, lymph nodes, and
spleen disordersHe started his medical career as a nursing student and has been trained at various reputed & prestigious healthcare Institutions in India. If you are looking for myeloma cancer treatment in Hyderabad, then head to Hematology and BMT Institute International. Hematology and BMT Institute International is a healthcare group that provides quality medical care to people every year. One of the most advanced healthcare centers in India, Hematology and BMT Institute International offers a comprehensive range of diagnostic and therapeutic technologies to facilitate efficient and accurate treatment.



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